I think I've seen some people on here say they've had trouble with glucosamine also. I don't want to name names because I'm just not certain I remember correctly. Mine get 900 mg of glucosamine daily but the started out on twice that for the first 4-6 weeks and seemed to tolerate it OK. Javadoo, or whatever her current name is, gives much higher doses, I think. When mine were on the "loading doses" I gave half in the morning and half at dinner time, in case that made a difference. Does Cooper have any symptoms or is this to try to head off problems?